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KMID : 0370019940080000113
Chung-Ang Journal of Pharmacal Sciences
1994 Volume.8 No. 0 p.113 ~ p.123
High Performance Liquid Chromatography of Coumarin Derivatives in Fraxini Cortex


Abstract
The coumarin derivatives in Fraxini Cortex(collected and commercial), which have been used for the therapies of inflammation, gout, neuralgia, and antipyretic, etc., were determined by HPLC under reversed-phase C_18 column with MeOH-H_2O-AcOH (31:69:0.4) as mobile phase.
Esculin, fraxin, coumarin glycosides, were contained with higher rate of 4.17% and 0.18% in the collected Fraxini Cortex than those of 1.80%, 0.06% and 0.86%, 0.01% in the commercial(¥°,¥²) respectively. On the other hand, in case of esculetin, fraxetin, coumarin aglycones, were distributed highly with 0.61%, 0.10% and 0.79%, 0.07% in the commercial(¥°,¥²) when compared with 0.33% and none in the collected respectively.
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